Clinical

 

Gas Plasma has been shown to have a greater microbial load reduction than antibiotics on wounds in RCTs(1) and has efficacy against biofilms(2,3). It has proven efficacy in management of infection in surgical site infections(4,5). Gas Plasma is also a broad spectrum antimicrobial (including  multi-resistant strains) and with a physical mode of action, resistance is unlikely(6).

Isbary BJD 2012 167,404-110 ; 2. Ermolaeva JMM 2011 60,7583 ; 3. Booth Wounds UK, 2015 ; 4. Rotering EWMA Bremen 2016,  5. Rotering WUWHS 2016 ; 6. Isbary BJD 2010 163, 78-82

Bibliography

Characterization of Microwave Plasma Torch for Decontamination, Tetsuji Shimizu, Bernd Steffes, René

Pompl, Ferdinand Jamitzky, Wolfram Bunk, Katrin Ramrath, Matthias Georgi, Wilhelm Stolz, Hans-Ulrich

Schmidt, Takuya Urayama, Shuitsu Fujii, Gregor Eugen Morfill, Plasma Process. Polym. 2008, 5, 577-582

 

A first prospective randomized controlled trial to decrease bacterial load using cold atmospheric argon plasma on chronic wounds in patients, G. Isbary, G. E. Morfill, H.-U. Schmidt, M. Georgi, K. Ramrath, J. Heinlin, S. Karrer, M. Landthaler, T. Shimizu, B. Steffes, W. Bunk, R. Monetti, J. L. Zimmermann, R. Pompl and W. Stolz, British J. Dermatol. 163 (1), 78-82 (2010).

 

Cold atmospheric plasma: A successful treatment of lesions in Hailey-Hailey disease, G. Isbary, G. Morfill, J. Zimmermann, T. Shimizu and W. Stolz, Archives of Dermatology 147(4):388-390 (2011).

 

Successful and Safe Use of 2 Min Cold Atmospheric Argon Plasma in Chronic Wounds: Results of A

Randomized Controlled Trial. Isbary, G., J. Heinlin, T. Shimizu, J. L. Zimmermann, G. Morfill, H-U. Schmidt, R. Monetti, B. Steffes, W. Bunk, Y. Li, T. Klaempfl, S. Karrer, M. Landthaler and W. Stolz,. British Journal of Dermatology, 2012. 167(2): p. 404-10.

 

A randomized two-sided placebo-controlled study on the efficacy and safety of atmospheric non-thermal argon plasma for pruritus, J. Heinlin, G. Isbary, W. Stolz, F. Zeman, M. Landthaler, G. Morfill, T. Shimizu, J. L. Zimmermann and S. Karrer, J Eur Acad Dermatol Venereol. 27 (3), 324-331 (2013).

 

Randomized placebo-controlled human pilot study of cold atmospheric argon plasma on skin graft donor sites, Heinlin J, Zimmermann JL, Zeman F, Bunk W, Isbary G, Landthaler M, Maisch T, Monetti R, Morfill, GE, Shimizu T, Steinbauer J, Stolz W, Karrer S. Wound Repair Reg 2013.

 

Cold Atmospheric plasma for local infection control and subsequent pain reduction in a patient with chronic post operative ear infection. Isbary G, Shimizu T, Zimmermann J, Hubertus T, Morfill G, Stolz W . New Microbes and New Infections (2013).

 

Cold atmospheric argon plasma treatment may accelerate wound healing in chronic wounds: Results of a retrospective in vivo randomized controlled study. Isbary G., Stolz W, Shimizu T, Monetti R, Bunk W, Schmidt H-U, Morfill GE, Klaempfl TG, Steffes B, Thomas HM, Heinlin J, Karrer S, Landthaler M, Zimmermann JL Clinical Plasma Medicine 2013 Dec; 1(2):25-30.

 

Randomized placebo-controlled clinical trial showed cold atmospheric argon plasma relieved acute pain and accelerated healing in herpes zoster, G. Isbarya, , , T. Shimizub, J.L. Zimmermannb, J. Heinlinc, S. Al-Zaabia, M. Rechfeldd, G.E. Morfillb, S. Karrerc, W. Stolza, Clinical Plasma Medicine, Volume 2, Issue 2, December 2014, Pages 50–55.

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